This is the ‘kings’ disease’ as it affects the affluent. It is a type of arthritis that affects the toe, knee and other joints. Your kidneys lose their ability to flush out the excess amounts of uric acid, partially. This uric acid crystallizes and lodges in the joints, thus causing joint pain. This joint gets hot, swollen and tender. This pain usually starts in the middle of the night and can last for hours and days at a stretch. But it can vanish quite quickly.